Pedal the Cause dollars at work! Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine recently announced the funding for eight new projects with $2 million of funding made possible by Pedal the Cause. Projects include research focused on prostate cancer, lymphoma and breast cancer, as well as a team science project with a focus on myeloproliferative neoplasms, a blood malignancy that can develop into acute myeloid leukemia.

Also included are two new clinical trials, one aiming to devise a more personalized treatment strategy for breast cancer in Black patients and another examining the efficacy of a novel drug treatment for patients with cutaneous T-cell lymphoma. This bring the total number of Pedal the Cause funded cancer research projects to 211!

“These projects will change the trajectory of cancer in powerful ways,” says Susan Ell, vice president and executive director of The Foundation for Barnes-Jewish Hospital. “We could not make this transformative, life-saving investment at Siteman Cancer Center without the support of our generous donors and our ongoing partnership with Pedal the Cause.”

Projects receiving SIP awards include:

• NeoTAILOR: A Phase II Biomarker-directed Approach to Guide Neoadjuvant Therapy for Patients with Stage II/III ER-positive, HER2-negative Breast Cancer
  Principal Investigator: Nusayba Bagegni, MD
• Phase I Study with an Expansion Cohort of EZH2 Inhibitor CPI-0209 (Tulmimetostat) in Patients with Mycosis Fungoides and Sézary Syndrome
  Principal Investigator: Neha Mehta-Shah, MD, MSCI
• Characterizing Rural Metastatic Breast Cancer Care: A Qualitative Analysis
  Principal Investigator: Ashley Housten, OTD, MSCI
• High Spatiotemporal Resolution Radioluminescent Dosimetry of Proton FLASH Radiotherapy for Pre-Clinical Studies
  Principal Investigator: Arash Darafsheh, PhD
• Clinical Molecular Imaging of the Prostate Cancer Microenvironment
  Principal Investigator: Joseph Ippolito, MD, PhD; Co-PI: Eric Kim, MD
• Understanding the Role of Mammogram Images in the Risk of Triple Negative Breast Cancer
  Principal Investigator: Shu (Joy) Jiang, PhD
• A Novel Feed-Forward Cycle that Drives Tumor Progression and Immune Evasion
  Principal Investigator: Jacqueline Payton, MD, PhD
• Intrinsic and Extrinsic Factors Driving Clonal Evolution and Disease Progression in Myeloproliferative Neoplasms
  Principal Investigator: Stephen Oh, MD, PhD

Learn more about these projects here, and read the full press release here.